PREPARATION RELEASE OF RBX GENTAMYCIN LOCAL DRUG DELIVERY SYSTEM AND ITS RELEASE EFFECT IN VIVO
- VernacularTitle:RBX-庆大霉素药物释放系统的研制及体内释放效应
- Author:
Liang SUN
;
Yunyu HU
;
Yu PAN
- Publication Type:Journal Article
- Keywords:
bone transplantation;
gentamycins;
drug delivery system
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To develop a biodegradable implant with both the ossific and anti infectious abilities. Antigen extracted bovine cancellous bone combined with bBMP as the center carrier was coated with either gelatin or poly ? caprolaton (PCL). They were then compounded with gentamicin. Their in vivo gentamycin releasing characteristics were assayed. There was an initial phase of rapid release of gentamycin within 24 hours, followed by a second phase of sustained but gradual diminution of drug release. Effective release of gentamicin from the PCL encapsulated RBX G LDDS may last 30 days in vivo . There was no significant difference in releasing rate between 30% gelatin and 40% gelatin in statistic. The results showed that RBX gentamycin possessed a fine in vivo gradual release property. Collaborated with its ossification activity, it could be considered as an ideal repair material for open fracture with bone defect.
