Changes of plasma levels of proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure
- VernacularTitle:心力衰竭患者血浆肾上腺髓质素前体N端20肽的变化
- Author:
Yuqi GAO
;
Zhiliang LI
;
Hongchao WU
- Publication Type:Journal Article
- Keywords:
Congestive heart failure Proadrenomedullin N terminal 20 peptide Drug treatment Radioimmunoassay
- From:
Chinese Journal of Practical Internal Medicine
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To study the changes of plasma levels of proadrenomedullin N terminal peptide(PAMP) in patients with congestive heart faillure(CHF) before and after drug treatment and its significance.Methods Plasma PAMP levels in 45 patients with CHF and 7 heathy control subjects were measured by specific radioimmunoassy.Results The plasma PAMP levels in patients with CHF were significantly decreased with the deterioration of cardiac function.Plasma PAMP levels in 45 patients in NYHA class Ⅳ(2 79?0 89pg/mL) were significantly lower than those in class Ⅱ(6 24?1 71pg/mL)?class Ⅲ(7 38?1 28pg/mL) and control subjects(8 56?2 44pg/mL)(P
