Advances on study of relation between hepatitis C virus and hepatocellular carcinoma
- VernacularTitle:丙型肝炎病毒与肝细胞癌关系研究进展
- Author:
Shineng ZHU
;
Yi LU
- Publication Type:Journal Article
- Keywords:
hepatitis C virus;
carcinoma,hepatocellular
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
It is estimated that there are about 0. 17 billion HCV infection cases worldwide. HCV sub-genotype 1b and 2a have been the most common genotypes found in the mainland China. The positive rate of HCV antigen in hepatocellular carcinoma (HCC)/corresponding non-cancer liver tissues in China is between 36. 2% (25/69)-72. 7% (48/66), which is associated with different detection methods. HCV associated HCC usually occurs along with chronic hepatitis→cirrhosis pathway. There was no doubt a correlation between the expression of HCV antigen and liver cell transformation, and the change of the functions of tumor-associated genes. These results show HCV is an important risk factor for development of HCC.
