Comparison of formation and morphologic features of digestive vacuoles and haemozoin between chloro-quine-sensitive and chloroquine-resistant strains of Plasmodium berghei
- VernacularTitle:伯氏疟原虫氯喹敏感株和抗性株虫体食物泡和疟色素形态及形成的比较
- Author:
Keqiang CHEN
;
Huaimin ZHU
;
Guanhong SONG
- Publication Type:Journal Article
- Keywords:
Plasmodium berghei;
chloroquine-sensitive strain;
chloroquine-resistant strain;
erythrocytic stage;
diges-tive vacuole;
haemozoin
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the morphologic foundation for differences in drug-resistance, virulence and immunity between chloroquine-sensitive (N) and chloroquine-resistant (RC) strains of Plasmodium berghei. Methods: The RC strain and the N strain were compared concerning the formation and morphologic features of digestive vacuoles and haemozoin with transmission electron microscope. Results: There was a single large digestive vacuole and multiple micro-single-mem-braned vacuole-like structures in the trophozoites of the N strain, and haemozoins centralized and fused during their schizo-gony were situated under the plasma membrane. Whereas there were few digestive vacuoles in the trophozoites of the RC strain, but with multiple micro-single-membraned vacuole-like structures instead. The RC strain formed obviously less hemo-zoins than that of the N strain and the hemozoins were not centralized and fused during the schizogony. Conclusion: The RC strain forms multiple single-membraned food vacuole-like structures in the trophozoites, and has different mechanism for detoxifying free heme with N strain and the features may be the foundation for the difference in drug-resistance, virulence, immunity between RC strain and N strain of Plasmodium berghei.
