Detection and clinical implication of minimal residual cancer cells in patients with solid tumors
- VernacularTitle:实体瘤患者微量残留癌细胞检测的临床应用
- Author:
Cuihong WANG
;
Zhengfeng YIN
- Publication Type:Journal Article
- Keywords:
minimal residual cancer cells;
solid tumor;
diagnosis;
therapy;
prognosis;
review literature
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
After surgical removal of a primary tumor the minimal residual cancer cells (MRCC) and metastases derived thereof are the actual targets for all theraputic approaches. Due to the great sensitivity and PCR-based detection systems, the molecular characterization of MRCC can provide information about their metastatic potential, availability of drug targets, drug sensitivity and development of therapy resistance, which will close the analytical gap between primary disease and the detection of metastases by conventional methods such as imaging procedures, and this will help therapy selection, monitoring of the treatment effects and predicting of the prognosis. Patients will benefit from a individualized therapy in the end.
