CaMKⅡ:A molecular switch of synaptic plasticity
10.3969/j.issn.1001-1978.2014.07.003
- VernacularTitle:钙调素依赖性蛋白激酶Ⅱ的分子调节与突触可塑性
- Author:
Wenbin HE
;
Junlong ZHANG
;
Longchuan YU
;
Naihong CHEN
- Publication Type:Journal Article
- Keywords:
calcium/calmodulin-dependent protein kinase Ⅱ;
autophosphorylation;
subcellular localization;
synaptic plastici-ty;
long-term potentiation;
learning and memory
- From:
Chinese Pharmacological Bulletin
2014;(7):897-900,901
- CountryChina
- Language:Chinese
-
Abstract:
Calcium/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ),which is an important protein kinase involved in learning and memory,is found in most tissues,but it is present in especially high concentrations in neurons.The relatively high expression of CaMKⅡin nervous system suggests it plays an im-portant role in the function of nervous system.This paper re-views the research development of the molecular structure of CaMKⅡ and its autophosphorylation,subcellular localization and its role in synaptic plasticity.
