Interferon-? combined with lamivudine in the treatment of chronic hepatitis
- VernacularTitle:干扰素?联合拉米夫定治疗慢性乙型肝炎的短期疗效及其影响因素
- Author:
Dan SHU
;
Daguo YANG
;
Zhiliang GAO
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatitis B, chronic;
Interferon alpha;
Lamivudine;
Drug therapy combination
- From:
Chinese Journal of Infectious Diseases
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
1.0 ?10 7 copies/ml than those with lower HBV DNA levels both in combination group and lamivudine group (52.0% vs 25.8%, P= 0.04; 63.2% vs 28.6%, P= 0.03). Necro-inflammatory activity, fibrosis and the expression of HBV DNA showed no correlation with response rate in combination group. Among those who had higher levels of HBV DNA expression, seroconversion rate in combination group is higher than that in lamivudine group (46.2% vs 9.5%, P= 0.03). Conclusions The efficacy of combination therapy appeared to be better in patients with at least moderately elevated baseline ALT, high level of HBV DNA as well as HBV DNA expression in hepatocytes. Combination therapy may delay or diminish the development of YMDD mutation-related resistance to lamivudine.
