The relationship between dexamethasone and expression of brain derive neurotrophic factor and its receptor gene in experimental bacterial meningitis
- VernacularTitle:地塞米松治疗与细菌性脑膜炎脑源性神经营养因子及其受体基因表达的关系
- Author:
Ling LI
;
Quanxiang SHUI
;
Shiqiang SHANG
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Brain-derived neurotrophic factor;
Gene expression;
Meningitis,Bacterial
- From:
Chinese Journal of Infectious Diseases
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between dexamethasone and brain derive neurotrophic factor gene in experimental bacterial meningitis. Methods To construct the models of bacterial meningitis in 3 weeks old rats(n=33),then 23 of them were administed antibiotic and antibiotic plus dexamethasone respectively. BDNF mRNA and TrkB mRNA in brain was detected by in situ hybridization methods,respectively. Results After administration antibiotics, the expression of BDNF mRNA and TrkB mRNA in brain tissue were less than that in brain after infection 5 d(P 0.05), the expression of TrkB mRNA was stronger than that in brain at 5 d after infection(P
