EXPERIMENTAL STUDY ON THE EFFECT OF HEAT ACCLIMATIZATION ON THE CONTENT OF SOD AND MDA IN DOG WITH GUNSHOT WOUNDS IN LIMBS IN HOT AND HUMID ENVIRONMENT
- VernacularTitle:高温高湿环境下热习服犬肢体火器伤后SOD、MDA含量变化的实验研究
- Author:
Xuhui ZHANG
;
Guoxian PEI
;
Kuanha WEI
- Publication Type:Journal Article
- Keywords:
military medicine;
tropical medicine;
wounds, gunshot;
acclimatization;
superoxide dismutase;
malondialdehyde
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the effect of heat acclimatization to the content of SOD and MDA in dogs with gunshot wound in limbs in hot and humid environment, eighteen Chinese mongrels were divided into 3 groups randomly according to the given environment: heat acclimatization(HA) group, normal environment(NE)group, and hot and humid environment(HHE) group. The contents of superoxide dismutast(SOD) and malonaldehyde(MDA) in muscle tissues of the gunshot wound track were assayed at 0, 1, 3, 4, 6, 8, 10, 14, 18 an 24h respectively after wounding. The results showed that the contents of MDA in both HA and HHE groups began to ascend on postinjury hour(PIH) 1, peaking at PIH10 in HA group and PIH6 in HHE group, with the former lower than the latter. There was no significant difference between the contents of MDA in the three groups at PIH18. The content of SOD in HA group began to rise immediately after injury, which was 1h earlier than that in the other two groups, and it was higher than that in HHE group after PIH4. The content of SOD was too low to be measured at PIH10 in HHE group, and this result was 4h earlier than that in the other two groups. In conclusion, SOD and MDA play an important role in the pathophysiological process of gunshot wound in hot and humid environment. Heat acclimatization can be favorable to mitigate pathophysiological changes, and it might be an effective method to prevent rapid deterioration of gunshot injuries in hot and humid environment.
