RESEARCH ON THE POLYMORPHISM PROPERTY OF CXCR4 LIGAND SDF1-? CODING REGION IN CHINESE HAN NATIONALITY
- VernacularTitle:中国汉族人SDF1-?编码区新多态性位点初步研究
- Author:
Mingxu LIU
;
Fusheng WANG
;
Weigu HONG
- Publication Type:Journal Article
- Keywords:
human immunodeficiency virus 1;
stromal cell derived factor 1;
gene polymorphism
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Forty five Han individuals were enrolled for the investigation of the polymorphism property of HIV 1 associated SDF 1? in Chinese Han nationality. Four exons of SDF 1? were cloned by PCR amplification using 4 pairs of primers, then sequenced respectively. DNAstar software was employed to analyze the sequencing results. One SNP and one thymidine deletion were identified in the coding region of SDF1 ?. The SNP was G→T at 192 with a frequency of 8.9%, resulting in replacing lysine to asparagine. The thymidine deletion was at 100 (100?T), which caused frame shift from the 34th amino acid and ending at the 59th amino acid. Both of them were discovered for the first time, and their influences on HIV 1 infection and AIDS progression remain to be explored.
