ELECTROPHYSIOLOGICAL STUDY OF NT3 GENE THERAPY FOR INJURED AUDITORY NEURONS IN THE COCHLEA AFTER INTENSIVE NOISE TRAUMA IN GUINEA PIG
- VernacularTitle:稳态噪声性听神经损伤后蜗内基因治疗的电生理研究
- Author:
Wei LUO
;
Jianjun SUN
;
Pi JIANG
- Publication Type:Journal Article
- Keywords:
gene therapy;
cochlea;
cochlear nerve;
noise induced hearing loss, protection;
action potentials
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the effectiveness of gene therapy for acoustic trauma induced by intensive noise, the replication defective adenovirus that carries human neurotrophin 3 cDNA(Ad NT3) was inoculated into the guinea pig cochlea 3 days after exposure. ABR and CAP were recorded after 14 days and 2 months, respectively. No difference was found 14 days after exposure. At the end of two months, the Ad NT3 treated animals showed less ABR threshold shift, lower CAP threshold and shorter CAP N1 latency by 100dBSPL click. The result suggested that Ad NT3 could be used to express the neurotrophins within the cochlea and reduce noise induced hearing loss in vivo .
