EFFECTS OF ANGⅡ/IFN-? ON EXPRESSION OF TGF-?R TYPE I OF RAT VSMC
- VernacularTitle:干扰素?及血管紧张素Ⅱ对大鼠血管平滑肌细胞表达转化生长因子?1型受体的影响
- Author:
Gang DING
;
Zhiming ZHU
;
Zuoq ZHANG
- Publication Type:Journal Article
- Keywords:
interferon ?;
angiotensin Ⅱ;
transforming growth factor beta;
receptor;
vascular smooth muscle cell
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor ?1 (TGF ?1) promotes the formation of extracellular medium(ECM).This study was designed to investigate the effects of angiotensinⅡ(AngⅡ) and Interferon ?(IFN ?) on expression of TGF ? Receptor type I(T?R I) in rat vascular smooth muscle cell(VSMC). We observed the changes of T?R I expression after 24h stimulation with AngⅡ(10 -7 M) and IFN ?(500U/ml) by Western blotting, and found that AngⅡ markedly stimulated expression of T?R I from 62 24?4 39 in control group to 103 06?9 34 in AngⅡ group (expressed in OD, P
