SIGNIFICANCE OF CHANGES IN Toll-LIKE RECEPTOR 2 IN RATS WITH POSTBURN STAPHYLOCOCCUS AUREUS SEPSIS AND ITS POTENTIAL SIGNAL TRANSDUCTION
- VernacularTitle:烫伤后金葡菌脓毒症大鼠Toll样受体2基因表达及其信号机制的研究
- Author:
Hongyun LI
;
Yongming YAO
;
Ning DONG
- Publication Type:Journal Article
- Keywords:
burns;
Toll-like receptor 2;
Staphylococcus aureus;
sepsis
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate changes in Toll-like receptor 2 (TLR2) gene expression in postburn Staphylococcus aureus infection, and its potential signaling mechanism, 68 male Wistar rats were randomly divided into four groups as follows: normal control group (n=6), scald control group (n=6), postburn sepsis group (n=36),AG126 treatment group (n=10) and pyrrolidine dithiocarbamate (PDTC) treatment group (n=10). Tissue samples from the liver, kidney and lung were collected from every group to determine TLR2 and tumor necrosis factor-? (TNF-?) mRNA expression. The results showed that TLR2 mRNA expressions in the liver, kidney and lung from postburn septic animals were up-regulated rapidly, peaking at 0.5-2 hours (P
