DETECTION AND LOCATION OF MELATONIN RECEPTOR IN HUMAN SKIN AND ITS MOLECULAR FEATURE
- VernacularTitle:人皮肤组织褪黑素受体的鉴定及生物学意义
- Author:
Yongquan SHI
;
Hui ZHANG
;
Zhimin LIU
- Publication Type:Journal Article
- Keywords:
melatonin, receptor;
skin
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to detect and localize melatonin receptor and its mRNA expression in the human skin, human skin was obtained from healthy volunteers. Immunohistochemistry and RT-PCR were applied to detect MR in human skin and to identify its subcellular distribution. Electrophoresis of RT-PCR product showed positive band of mt 1 subtype in human skin. The subtype of MR, mt 1was present in the membrane, cytosol and nucleus of skin cells as shown by immunohistochemistry. It is suggested that skin is the target organ of melatonin.
