Different colony stimulating factor on the effect of acute myeloid leukemia in patients with complete remission of dendritic cell subsets
10.3760/cma.j.issn.1008-6706.2014.16.033
- VernacularTitle:不同集落刺激因子对完全缓解急性髓系白血病患者树突状细胞亚群的影响
- Author:
Li CHEN
;
Liyin GUO
;
Li WANG
;
Wenjing ZHANG
;
Hongxiang WANG
- Publication Type:Journal Article
- Keywords:
Colony-stimulating factors;
T-lymphocyte subsets;
Leukemia,myeloid
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(16):2473-2474,2475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the granulocyte colony stimulating factor ( G-CSF ) and granulocyte macro-phage colony stimulating factor ( GM-CSF) in complete remission of acute myeloid leukemia ( AML) patients with den-dritic cells(DC)changes in the function and its subsets .Methods 36 cases of complete remission according to AML patients were randomly divided into 3 groups,G group was given G-CSF 200g/d,subcutaneous injection ,GM group were given GM-CSF 200g/d,subcutaneous injection ,the control group were injected with normal saline .The curative effects were compared.Results The expression of G in group DC,CD83 and CD86 on surface of CD80 were lower than that in GM group and C group (t=4.34,5.43,4.54,4.54,5.25,3.54,all P<0.05),GM group,DC expression of CD11c was higher than that of G group and C group (t=4.54,4.27,all P<0.05).G group and GM group DC in promoting lymphocyte proliferation were higher than those in C group (t=4.54,5.64,all P<0.05);group GM DC to promote the ability of CD4 +T lymphocyte proliferation was higher than that of G group (t=3.54,P<0.05).ELISA assay,GM group DC secretion of IL-12 than that of group G and C group;group G DC secretion of IL-10 was higher than that of GM group and C group (t=3.54.4.23,4.32,3.87,all P<0.05).Conclusion G-CSF and GM-CSF can make the complete remission in patients with AML subgroup DC shift ,the bias of G-CSF DC2 and certain immuno-suppressive effect ,while GM-CSF DC subsets of DC 1 and promotes cell immune deviation .
