EXPRESSION OF TGF-?1 AND ?-SMA IN LIVER OF CHRONIC HEPATITIS B
- VernacularTitle:慢性乙型肝炎肝组织中TGF-?1及?-SMA的表达变化
- Author:
Wenbi CHEN
;
Jiachun YAN
;
Ruixia TIAN
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
pathologic vascular proliferation;
transforming growth factor;
smooth muscle actin
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the effect of vascular proliferation and reconstruction in chronic hepatitis B (CHB), immunohistochemical staining and in situ hybridization were used. The expression of transforming growth factor (TGF-?1) and smooth muscle actin (?-SMA) in livers of CHB were observed. The results showed that TGF-?1 and ?-SMA were related with degeneration of hepatocytes, intrahepatic vascular fibrosis and hepatic sinusoidal capillarization. The expression degree and range of TGF-?1 and ?-SMA increased with the exacerbation of liver lesion. These results suggest that vascular proliferation and reconstruction may play important roles during the process of CHB.
