Efficacy of long-term cyclosporin A treatment on severe aplastic anemia.
- VernacularTitle:环孢菌素A长程治疗重型再生障碍性贫血临床观察
- Author:
Xinyou ZHANG
;
Dalong ZHANG
;
Ming WU
- Publication Type:Journal Article
- Keywords:
Aplastic anemia,Severe Cyclosporin A Long-term treatment
- From:
Chinese Journal of Practical Internal Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and tolerability of long-term application of cyclosporin A(CsA) in patients with severe aplastic anemia(SAA).Methods 39 patients with SAA were treated with CsA and androgen.The efficacy at 3-month,6-month,1-year,2-year treatment was evaluated.Main side effects of CsA were assessed.Results An overall response rate to CsA was 45.5% in the patients with SAA.19.1% of patients showed response to the treatment at 3 months,45.0% at 6 months,56.3% at 1 year,83.3% at 2 years,respectively.The early mortality rate in SAA Ⅰ patients was significantly higher than that in SAA Ⅱ patients(P
