Control study of Beraprost Sodium and atorvastatin in treatment with TIA combined carotid plaques
- VernacularTitle:贝前列素钠联合阿托伐他汀治疗TIA合并颈动脉斑块的对照研究
- Author:
Jinghong ZHEN
;
Wenjun WU
;
Ziyu SHE
;
Qundi LIANG
;
Junli PAN
- Publication Type:Journal Article
- Keywords:
beraprost sodium;
atorvastatin;
transient ischemic attact;
carotid plaques
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):125-126,129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Beraprost Sodium and atorvastatin in the treatment of TIA combined carotid plaques. Method 60 cases in our hospital with TIA and carotid artery plaques were randomly divided into observation group and control group, 30 cases in each group. The observation group was received beraprost natriuretic peptide and atorvastatin calcium therapy, the control group was treated with atorvastatin calcium. 12 months later,two groups were compared with carotid plaque area change and coagulation conditions. Results Carotid plaque area in observed group was significantly less than the control group (P<0.05). The differences of platelet agglutination test(PAgT), fibrinogen(Fg) , hypersensieive 3 C-reaction protein, total cholesterol(TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), TIA recurrence rate and incidence of ischemic stroke between two groups after treatment were statistically significant (P<0.05). Conclusion Beraprost Sodium and atorvastatin has a good effect in reducing carotid plaques area, adjusting blood fat and preventing TIA and ischemic stroke, It is worthy to clinical popularization and application.
