The effects of PLC on the ultrastructure of platelets
- VernacularTitle:磷酯酶C对家兔血小板聚集和超微结构的影响
- Author:
Jianhua SONG
;
Mingkai CHEN
;
Changgao WANG
;
Songbai SUN
;
Tao CHEN
- Publication Type:Journal Article
- Keywords:
PLC;
platelet;
ultrastructural changes;
inhibition of platelet aggregation
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of PLC on ultrastructure of platelets. METHODS The effects of PLC on ADP induced platelet aggre-gation were detected by tubidmetry; the ultrastru-cture changes of platelet were analyzed by electron microscope. RESULTS The rate of PLC inhibited significantly platelet aggregation by ADP induced is 86 03%?12 06% and 82 47%?5 49%. Pseudopodia can inhibit by 0 5 U PLC, at this group increase in the number of the granules associated with enhanced intensities of their electron densities and smaller dilated canalicular system. compared with normal saline group. In the 2 5 U PLC group the platelet morphology and ultrastructure approach blank group. The platelet is very smooth. PLC can inhibit producing pseudopodia-like process and the releasing of granules. Dilated canalicular system is similar to blank group, But it was different to normal group. CONCLUSION It's showed that PLC can significantly inhibit platelet aggregation and ultrastructural changes.
