Study on immunomodulation and antitumor activity of paeonol in HepA tumor mice
- VernacularTitle:丹皮酚对HepA荷瘤小鼠免疫调节和抑瘤作用研究
- Author:
Guoping SUN
;
Yuxian SHEN
;
Lingling ZHANG
;
Aiwu ZHOU
;
Wei WEI
;
Shuyun XU
- Publication Type:Journal Article
- Keywords:
paeonol;
antitumor;
IL-2;
TNF-?
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study immunomodulation and antitumor activity of paeonol. METHODS Paeonol was administered singlely to HepA bearing mice. 14 d later, the inhibition of tumor weight were observed. IL-2 and TNF-? content in serum, IL-2 secretion by splencytes, TNF-? production by PM? were measured by RIA. RESULTS Paeonol possess markedly inhibitory activity on the growth of HepA tumor in mice, and IL-2 and TNF-? were induced signficantly. CONCLUSION Paeonol has the effects of antitumor. This effect may be derived from inducing IL-2 and TNF-? production.
