TF modiifed doxorubicin and Rg3 loaded liposome for gastric cancer targeting and therapy
- VernacularTitle:转铁蛋白修饰共载阿霉素和Rg3脂质体靶向抑制胃癌细胞增殖
- Author:
Hua LI
;
Shilin HU
;
Hailong WANG
;
Zhitu ZHU
- Publication Type:Journal Article
- Keywords:
transfferin;
doxorubicin;
Rg 3;
liposome
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):9-11,15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare TF conjugated doxorubicin and Rg 3 loaded liposome and evaluate their properties and effect on the treatment of gastric cancer. Method The liposomes were prepared by thin iflm hydration method. The efifciency of cellular uptake on MKN-28 cells in vitro was evaluated. The anti-proliferation efifciency of TF-LP-DOX/Rg 3 was evaluated by MTT assay. Tumor spheroids were used to evaluate anti-tumor ability of TF-LP-DOX/Rg 3. Results The result demonstrated that TF-LP uptaken by MKN-28 were 2.9 times higher than that of LP(P<0.01). The MTT assay and the inhibition of tumor spheroids in vitro conifrmed strong inhibitory effect of TF-LP-DOX/Rg 3. Conclusion TF-LP-DOX/Rg 3 easily prepared and it is a potential delivery system for the treatment of gastric cancer.
