Study on transdifferentiation of renal tubular epithelial cells in patients with chronic aristolochic acid nephropathy
- VernacularTitle:慢性马兜铃酸肾病患者肾小管上皮细胞转分化的研究
- Author:
Wen CHEN
;
Yipu CHEN
;
Jing ZHANG
;
Hong CHENG
;
Bao DONG
;
Wanzhong ZOU
- Publication Type:Journal Article
- Keywords:
Fibrosis;
Aristolochic acid;
Renal interstitium
- From:
Chinese Journal of Nephrology
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between tubular cells transdifferentiation and renal interstitial fibrosis in patients with chronic aristolochic acid nephropathy (CAAN). Methods Specimens from renal biopsies of 10 CAAN patients with serum creatinine level of (309. 41 ? 164. 44) ?mol/L were performed to examine the extent of renal interstitial fibrosis by Masson staining, the expression of collagen types Ⅰ and Ⅲ by sirius red staining, and the expression of cytokeratin(CK), ?-smooth muscle actin (a-SMA), vimentin (Vim) and transforming growth factor-? 1 (TGF-?1) by immunohistochemical staining. Quantitative analysis by computer image analytic system or semi-quantitative analysis were used to evaluate the data. Results There was positively significant correlation between interstitial collagen types Ⅰ and Ⅲ and serum creatinine level ( r =0. 890, P
