Effect of Ginsenoside-Rg combined with oxaliplatin and sorafenib on hepatic carcinoma cell apoptosis
- VernacularTitle:人参皂苷Rg3联合奥沙利铂和索拉非尼对肝癌细胞凋亡的影响
- Author:
Jianxun BAO
;
Haofei WANG
;
Yunjuan HUANG
- Publication Type:Journal Article
- Keywords:
Ginsenoside-Rg;
oxaliplatin;
sorafenib;
hepatic carcinoma;
apoptosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):41-42,45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect of Ginsenoside-Rg combined with oxaliplatin and sorafenib on hepatic carcinoma cell apoptosis. Method Ginsenoside-Rg, oxaliplatin and sorafenib were divided into single drug group, two drugs group and three drugs group to act on hepatic carcinoma cell. Multiplication, prophase apoptosis, middle and advanced stage apoptosis were observed. Results To combine three drugs could improve hepatic carcinoma cell inhibition ratio, apoptosis ratio, apoptotic index compared to those of two drugs group or single drugs group(P<0.01). Conclusion To combine Ginsenoside-Rg, oxaliplatin and sorafenib can improve hepatic carcinoma cell inhibition ratio.
