Renoprotective effect of irbesartan on tubulointerstitial fibrosis in rats with adriamycin-induced nephropathy
- VernacularTitle:依贝沙坦对阿霉素肾病大鼠肾小管间质的保护作用
- Author:
Jili ZHU
;
Ruhan JIA
;
Xueyu WANG
- Publication Type:Journal Article
- Keywords:
Adriamycin-inducednephropathy;
Tubulointerstitialfibrosis;
Matrixmetallopriteinase-9;
Tissue inhibitors of metalloproteinase-1;
Irbesartan
- From:
Chinese Journal of Nephrology
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the renoprotective effect of irbesartan on tubulointerstitial fibrosis in rats with adriamycin-induced nephropathy and its possible mechanism. Methods Rats received twice-intravenous injections of adriamycin(ADR) after the right kidney was removed. Those rats were randomly assigned to irbesartan treatment group and nephropathy group. Treatment group received 50 mg? kg-1 ? d-1 irbesartan for 4 weeks. Rats with sham operation served as normal control. Proteinuria and serum creatinine of were measured after 4 weeks. Renal histopathological changes were evaluated as well. Immunohistochemistry was used to examine the protein expression of TGF-?1, MMP-9 and TIMP-1. The mRNA levels of MMP-9 and TIMP-1 were detected by in situ hybridization. Results Proteinuria of treatment group decreased significantly as compared to nephropathy group. TGF-?1, TIMP-1 and MMP-9 were significantly lower than that of nephropathy group in tubulointerstitium and consistently associated with tubular degeneration and interstitial fibrosis progressed. Conclusion Irbesartan has a renoprotective effect on tubulointerstitial fibrosis by modulating the ECM degradation.
