Anticonvulsant action of L-histidine in mice
- VernacularTitle:左旋组氨酸在小鼠的抗惊厥作用
- Author:
Aizhen WU
;
Huijing WANG
;
Minghui YAO
- Publication Type:Journal Article
- Keywords:
pharmacology;
L-histidine;
convulsion;
pentylenetetrazole;
dl-chlorpheniramine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the anticonvulsant action of L-histidine in mice. METHODS: The anticonvulsant effect of L-histidine, and the antagonism of dl-chlorpheniramine to L-histidine were observed in convulsion mice induced by pentylenetetrazole (PTZ) and electric stimulation. RESULTS: L-histidine exerted remarkable anticonvulsant action with dose-response relationship in convulsion mice induced by pentylenetetrazole and electric stimulation, and the action was partly antagonized by dl-chlorpheniramine. CONCLUSION: L-histidine has anticonvulsant effect, and the action was partly antagonized by dl-chlorpheniramine, suggesting that L-histidine can pass the BBS and enter the central nervous system.
