Comparison between s.przewalsii maxim injection and s.miltiorrhize bunge injection on the protection on acute focal cerebral ischemia of rats and the effect against lipide peroxidation
- VernacularTitle:甘西鼠尾草注射液和丹参注射液抗大鼠急性脑缺血和抗脂质过氧化作用的比较
- Author:
Tijuan CHENG
;
Zhiyong YANG
- Publication Type:Journal Article
- Keywords:
pharmacology;
s.przewalsii maxim injection;
s.miltiorrhize bunge injection;
middle cerebral artery occlusion;
acute focal cerebral ischemia;
malondialdehyde;
superoxide dismutase;
hydroxyl radical
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the effect of s. miltiorrhize bunge injection (SMBI) and s. przewalsii maxim injection (SPMI) on acute focal cerebral ischemia in rats, and to study the mechanism of the actions of two agents. METHODS: Acute focal cerebral ischemia model was made by middle cerebral artery occlusion (MCAO) in rats, and cerebral infarction volume was determined quantitatively by computer microscopical image analysis instruments. MDA content in serum was determined by TBA colorimetric analysis. SOD content in serum was studied by radioimmunity method. The scavenging effect of hydroxyl radical (?OH) was measured by electron spin resonance technique (ESR). RESULTS: SMBI and SPMI could markedly reduce infarction volume after occlusion of middle cerebral artery and MDA content in serum in rats. SMBI could elevate SOD content in serum. Two injections could markedly inhibit the formation of hydroxyl radical (?OH),and the effect of SPMI was better than that of SMBI. CONCLUSION: The effects of both SMBI and SPMI are similar, and it is possible that SPMI as a satisfactory substitute for SMBI.
