Effects of different penetration enhancer on penetration of ciclopirox olamine and salysic acid in percutaneous penetration
- VernacularTitle:不同透皮促进剂对环吡酮胺和水杨酸体外经皮渗透性的影响
- Author:
Xiaolong FENG
;
Hui WANG
;
Huiming ZHU
- Publication Type:Journal Article
- Keywords:
pharmacology;
salysic acid;
ciclopirox olamine;
percutaneous absorption;
deposit effect
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the enhancing effect of penetration enhancer on percutaneous absorption of antifungal agents. METHODS: Percutaneous penetration experiment was performed on device in vitro, and the deposit effects were observed with vivoperception. RESULTS: Combination of 1-menthol (1%) and azone (1%) showed the best effect on percutaneous absorption of cidopicox olamine, and 1-menthol (1%) had the best effect on percutaneous absorption of salysic acid. The compound penetration enhancer, consisting of 1-menthol (1%), azone (1%), propylene glycol ( 2.5%) and oleic acid ( 2.5%), had prominent action on absorption of cidopirox olamine through rabbit skins, and shorten the lag times obviously. CONCLUSION: L-menthol and azone can significantly enhance the percutaneous absorption of both salysic acid and cidopicox olamine. Combination of 1-menthol and azone can further increase the absorption.c
