Effect of hesperidin on locomotor activity of mice with infective brain injury induced by LPS
10.3969/j.issn.1671-8348.2014.16.019
- VernacularTitle:感染性脑损伤中橙皮苷对小鼠自主活动的影响
- Author:
Hongyan DONG
- Publication Type:Journal Article
- Keywords:
brain-inj-uries;
hesperidin;
locomotor-activity
- From:
Chongqing Medicine
2014;(16):2026-2027,2031
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hesperidin on the locomotor activity of mice with infective brain injury induced by li-popolysaccharide (LPS)in the dark field environment.Methods 45 ICR mice were randomly divided into 3 groups:Saline group, LPS group and LPS+Hesperidin group,15 mice in each group.The moving distance and the number of crossing line in the dark field were recorded using the ZH-ZFT locomotor activity video analysis system.ResultsThe LPS group had significantly shorter moving distance as well as lower frequency of the number of crossing line than those of the Saline group(P<0.05);compared with the LPS group,the Hesp group moved longer and crossed line more frequently,the differences between the two groups had statisti-cal significance (P<0.05).Conclusion Hesperidin could significantly improve the capacity for action in the dark field of mice with infective brain inj ury induced by LPS.
