EFFECT OF PENTOXIFYLLINE ON THE EXPRESSIONS OF SEVERAL INFLAMMATORY CYTOKINE GENES IN RATS WITH SEPSIS-INDUCED ACUTE LUNG INJUR.
- VernacularTitle:脓毒症性肺损伤大鼠炎性细胞因子的变化及己酮可可碱的干预作用
- Author:
Jiancheng XU
;
Baoling MAO
;
Guisheng QIAN
- Publication Type:Journal Article
- Keywords:
acute respiratory distress syndrome;
cytokines;
sepsis;
pentoxifylline
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of TNF ?, IL 1?, IL 6 and IL 8 mRNA in the lung,and the levels of TNF ?, IL 1, IL 6 and IL 8 in serum of rats with sepsis induced acute lung injury(ALI), and to examine the effect of pentoxifylline on the production of these cytokines. The expressions of TNF ?, IL 1?, IL 6 and IL 8 mRNA were detected with dot blot.The levels of TNF ?, IL 1?, IL 6 and IL 8 were examined with ELISA. Compared to the sham operation group, TNF ?, IL 1?, IL 6 and IL 8 mRNA expression in sepsis group were increased evidently( P
