THE CHANGES IN IL-13 CONTENT IN PLASMA IN RATS WITH ACUTE LUNG INJURY INDUCED BY LIPOPOLYSACCHARIDE
- VernacularTitle:脂多糖介导的急性肺损伤大鼠血浆IL-13含量的变化
- Author:
Qi LI
;
Guisheng QIAN
;
Qin ZHANG
- Publication Type:Journal Article
- Keywords:
acute respiratory distress syndrome;
lipopolysaccharides;
interleukin 13
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the interleukin 13(IL 13) content in plasma in rats with acute lung injury (ALI) induced by lipopolysaccharide (LPS), Wistar rats were given increasing doses of LPS (2mg/kg,4mg/kg,6mg/kg,8mg/kg) to produce ALI. The respirtory rate,PaO 2 ,wet weight/dry weight (W/D) of the lung, and pathological changes in the lung were observed. ELISA was used to determine plasma IL 13. It was found that: (1)ALI could be produced in rats with LPS, but ARDS occurred only when the dose of LPS reached 6mg/kg. or larger. (2)LPS produced an elevation of the content of IL 13 in plasma in rats, peaking when the dose of LPS reaching 6mg/kg or over. These results suggested that LPS might induce ALI in rats, and ARDS could be produced when the dose of LPS reached ≥6mg/kg. (3)The high increase in plasma IL 13 content might play an important role in producing ARDS induced by LPS.
