CHANGES IN IL-10 CONTENT IN PLASMA IN RATS WITH ACUTE LUNG INJURY INDUCED BY OLEIC ACID AND LIPOPOLYSACCHARIDE
- VernacularTitle:油酸-内毒素介导大鼠急性肺损伤及血浆IL-10含量的变化
- Author:
Qi LI
;
Guisheng QIAN
;
Qin ZHANG
- Publication Type:Journal Article
- Keywords:
acute respiratory distress syndrome;
lipopolysaccharides;
oleic acid;
interleukin 10
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the interleukin 10 (IL 10) content in plasma in rats with acute lung injury(ALI) induced by oleic acid (OA) and lipopolysaccharide(LPS). OA (0.2ml/kg) and LPS (2mg/kg) was given to Wister rats to produce ALI. The respirtory rate,PaO 2 , wet weight/dry weight (W/D) of the lung, and pathological changes were observed, and IL 10 was determined with enzyme linked immunosorbent assay (ELISA). The results showed that ALI was produced in rats with OA+LPS, and there was a significant increase in IL 10 content in plasma in rats, especially in OA+LPS/4h group. The above results suggested that OA+LPS might produce ALI in rats, and the development of ALI was related to an obvious increase of the IL 10 content in plasma.
