INHIBITION OF LPS-INDUCED ACTIVATION OF NF-?B IN THE LUNG BY POLYCLONAL ANTIBODY TO RAT LIPOPOLYSACCHARIDE BINDING PROTEIN.
- VernacularTitle:抗LBP多抗对LPS诱导的肺组织NF-?B活化的抑制作用
- Author:
Yongwang LI
;
Li MA
;
Demin ZHANG
- Publication Type:Journal Article
- Keywords:
lipopolysaccharides;
lipopolysaccharide binding protein;
antibody;
NF kappa B
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effects of polyclonal antibodies to rat LPS binding protein on LPS induced activation of NF ?B and production of TNF ? and IL 6 in the lung. The activation of NF ?B and the contents of TNF ? and IL 6 were measured by electrophoretic mobility shift assay and ELISA respectivly. We found that both the activity of NF ?B and the levels of TNF ? and IL 6 in the lung were significantly decreased by the antibodies when used at early stage, but not at late stage after LPS challenge. These data indicated that the antibodies to LPS binding protein might have a potential value in the prevention of acute lung injury as a result of LPS challenge.
