STUDY ON THE MECHANISM OF DETRUSOR INSTABILITY: NEUROGENIC OR MYOGENIC?
- VernacularTitle:逼尿肌不稳定的机制研究——神经源性?肌源性?
- Author:
Bo SONG
;
Xin LI
;
Gongku QIU
- Publication Type:Journal Article
- Keywords:
detrusor instability;
bladder outlet obstruction;
bladder, neurogenic
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the mechanism of detrusor instability, using an apparatus to measure energy regulated tonicity and length of muscle strip in vitro , detrusor instability in bladder outlet obstruction (BOO) and spinal cord injuries (SCI) after pharmacological intervention was studied. The detrusor of both groups contracted under definite tension. Contraction of DI strips occurred under lower tension and under same tension the frequency of contraction was higher in DI detrusor than the normal one. There were no obvious changes when the detrusor strips were treated with M receptor antagonists, ATP or VIP. Muscarinic receptor agonist could increase the excitability of detrusor. The increase of detrusor excitability plays a major role in the occurrence of DI. The excitability is independent on neurogenic factors.
