RELATIONSHIP BETWEEN DENSITY OF MUSCARINIC RECEPTOR SUBTYPE AND BLADDER INSTABILITY IN RATS
- VernacularTitle:大鼠不稳定膀胱与毒蕈碱受体亚型密度关系的实验研究
- Author:
Gensheng LU
;
Bo SONG
;
Xiy JIN
- Publication Type:Journal Article
- Keywords:
detrusor unstability;
receptors, muscarinic;
density
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the relationship between the density of muscarinic receptor (MR) subtype and the occurrence of bladder instability. The rat model of unstable bladder was established, and the density of MR subtype was determined in normal and unstable bladders. The results showed that there were only m 2 RNA and m 3 RNA present in the detrusor of normal and unstable bladders, and m 1, m 2 or m 3 mRNA subtypes were not detected. In the normal bladder, the amount of m 2 RNA (1 67?0 42) was obviously greater than m 3 RNA (0 64?0 19), and the ratio of them was 2 59∶1. In the unstable bladder, the density of both m 2 and m 3 increased to (2 03?0 65) and (1 53?0 46) respectively, and the increase of m 3 was more significant ( P
