THE RELATIONSHIP BETWEEN HLA-DRBI*07 ALLELES AND SUSCEPTIBILITY TO HBV IN THE HAN NATIONALITY IN GUANGDONG PROVINCE
- VernacularTitle:HLA-DRB1*07与广东汉族人慢性乙型肝炎相关性的研究
- Author:
Yi QIAN
;
Lian ZHANG
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
HLA antigens;
interferons;
interlukins
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the relationship between HLA DRB1*07 and the susceptibility to HBV in the Han nationality in Guangdong Province. 100 chronic HBV carrier individuals, 21 HBV spontaneously cleared individuals and 70 HBV unexposed individuals all of Han nationality in Guangdong Province were entered in this study. The expression of HLA DRB1*07 alleles were detected by polymerase chain reaction sequence specific primer, and IFN ? and IL 4 levels in plasma of HBV chronic carrier individuals were measured by using ELISA kits. The results showed that the positive rate of HLA DRB1*07 in chronic HBV carriers was 30%, which was markedly higher than that in HBV spontaneously cleared individuals(4 76%) and HBV unexposed individuals (8 5%) as well ( P
