INFLUENCE OF POPOFOL ON THE CONTENTS OF NEURON-SPECIFIC ENOLASE IN SERUM AND CEREBROSPINAL FLUID OF RABBITS WITH BRAIN INJURY
- VernacularTitle:异丙酚对脑创伤家兔血及脑脊液神经元特异性烯醇化酶含量的影响
- Author:
Xiuzhen LIU
;
Tiande YANG
;
Zhuoqian WANG
- Publication Type:Journal Article
- Keywords:
propofol;
craniocerebral trauma;
phosphopyruvate hydratase
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effect of propofol on the change in neuron specific enolase(NSE) contents in the serum and cererospinal fluid(CSF) of rabbits suffering from brain injury, so as to explore the protective effect of propofol on the brain, 20 New Zealand rabbits were inflicted with brain injury and randomized into control group and propofol treatment group ( n =10 each). Samples of serum and CSF were collected before trauma and 4h, 24h, 48h, 72h and one week following trauma respectively. The contents of NSE in serum and CSF were measured by enzyme immunoassay (EIA) method. The results showed that the content of NSE in serum at 24h, 48h, 72h and one week, and that in CSF from 4h to one week after trauma in control group were elevated significantly as compared with those before trauma ( P
