Invesitigation of the effects of Compound Danshen on endothelins and 6-Keto-PGF_(1?) of patients with pulmonary heart disease
- VernacularTitle:肺心病患者血浆内皮素和6-酮-前列腺素_(1?)水平及复方丹参对其的影响
- Author:
Xiaohui LIU
;
Hongru ZHAO
- Publication Type:Journal Article
- Keywords:
Endothelins;
6 Keto PGF 1?;
Pulmonary heart disease;
Compound Danshen
- From:
Chinese Journal of Respiratory and Critical Care Medicine
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of endothelin and 6 Keto PGF 1? of patients with pulmonary heart disease and effects of Compound Danshen,to study the role of ET 6 Keto PGF 1? in pulmonary heart disease and pulmonary artery hypertension,and explore a safe and effective drug for pulmonary artery hypertension Methods 40 patients with CPHD and 30 patients with COPD as well as 20 healthy persons as control whose levels of plasma ET and 6 Keto PGF 1? were measured by radioimmunization,meanwhile,PaO 2 was measured by blood gas analyze instrument Results The level of ET in CPHD was higher than that in COPD and healthy group,company with the lower level of 6 Keto PGF 1? After treatment with Compound Danshen,the level of ET was reduced and 6 Keto PGF 1? was elevated Conclusions The balance between ET and PGI is important in modulating pulmonary circulation Compound Danshen can reduce pulmonary artery tension through protecting endothelium,decreasing ET,and increasing PGI 2
