Effects of thalidomide on the expressions of basic fibroblast growth factor in human lung adenocarcinoma cell line A_(549) and cisplatin-resistant cell line A_(549) DDP
- VernacularTitle:反应停对人肺腺癌亲代及耐顺铂细胞系碱性成纤维细胞生长因子表达影响
- Author:
Xiping LI
;
Xuyi LIU
;
Jie WANG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Thalidomide;
Basic fibroblast growth factor
- From:Chinese Journal of Respiratory and Critical Care Medicine
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the effects of thalidomide on the expressions of basic fibroblast growth factor(bFGF) in parental and cisplatin resistant human lung adenocarcinoma cell line A 549 and A 549 DDP Methods RT PCR and lmmunohistochemistry were used to detect the bFGF mRNA and protein expression in A 549 and A 549 DDP Results bFGF mRNA expression levels and protein expressions in A 549 and A 549 DDP were all significant reduced after treatment of thalidomide (6 ?g/ml)(all P
