Clinical application of interferon gamma release assays for diagnosis of latent tuberculosis infection in children
- VernacularTitle:γ干扰素释放试验在幼儿隐性结核感染诊断中的临床价值分析
- Author:
Yuanhua YU
;
Yonghui WANG
;
Xiaohong XIONG
;
Yu HUANG
- Publication Type:Journal Article
- Keywords:
interferon gamma release assays;
latent tuberculosis infection;
tuberculin skin test
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):103-104,107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of interferon gamma release assays in early childhood diagnosis of latent tuberculosis infection.Methods 33 patients with suspected latent tuberculosis infection and 35 patients with active tuberculosis infection in our hospital from January 2012 to March 2013 were selected.During the same period selected 30 healthy children as a control group.Respectively were given sputum smear analysis,tuberculin skin test (TST)and vinterferon release assay (IGRA).Compare the positive rate of different methods. Results In suspected latent tuberculosis group,IGRA test results were significantly higher than TST and sputum smear method(P<0.05);in active tuberculosis infection group, IGRA test results were significantly higher than TST and sputum smear(P<0.05 );in healthy control group,TST test results were higher than the IGRA,it is because of patients had been vaccinated with BCG.Conclusion IGRA can be used as one way to diagnosis the latent tuberculosis infection.
