Clinical efficacy analysis of methotrexate and mifepristone in treatment of ectopic pregnancy
- VernacularTitle:甲氨喋呤与米非司酮联合治疗异位妊娠的临床效果分析
- Author:
Jinhong ZHENG
;
Hong ZHANG
;
Jinxiang JIANG
- Publication Type:Journal Article
- Keywords:
methotrexate;
mifepristone;
combination therapy;
ectopic pregnancy
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):130-131,134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of methotrexate and mifepristone in treatment of ectopic pregnancy. Methods 58 cases with ectopic pregnancy admitted in the Second People's Hospital in Putuo district of Zhoushan city from February 2010 to February 2012 were randomly divided into observation group and control group,each had 29 cases. Control group were received methotrexate 1 mg/kg or 50 mg/m2 once a day by intramuscular injection,observation group were given both methotrexate and mifepristone treatment,the mifepristone was given one piece a day and each piece is 75 mg. the treatment success,b-HCG returned to normal time,normal pregnancy and the occurrence of complications were compared between two groups. Results The treatment success and normal pregnancy rate in observation group were significantly higher than control group(P<0.05),b-HCG returned to normal time was significantly shorter than control group (P<0.05 ). There were no obvious adverse reactions in both two groups, observation group had one light nausea,and control group had one light nausea and one case with alanine aminotransferase (ALT)slightly increased phenomenon,those patients were all back to normal on their own without treatment,the difference of adverse reaction rate between two groups was not significant. Conclusions Methotrexate and mifepristone has good efficacy and are safe and reliable in,treatment of ectopic pregnancy.
