Abnormal expression of costimulatory molecules CD_(28)and CD_(137)on PBMC from patients with chronic nephritis
- VernacularTitle:慢性肾炎患者外周血共刺激分子CD_(28)和CD_(137)水平变化研究
- Author:
Huaying SHEN
;
Jixiang DONG
;
Yin WANG
- Publication Type:Journal Article
- Keywords:
Chronic nephritis Costimulatory molecules CD 28 CD 137
- From:
Chinese Journal of Practical Internal Medicine
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the expression features and roles of the costimulatory molecules and T lymphocyte subsets from patients with chronic nephritis.Methods The expression of the costimulatory molecules CD 28 and CD 137 on PBMC (peripheral blood mononuclear cells) and T lymphocyte subsets from 52 patients with chronic nephritis were studied by immunophenotyping and flow cytometry analysis.Results The T lymphocyte subsets from patients with chronic nephritis showed an obvious imbalance with reversing CD 4/CD 8 ratio,decreasing CD + 4T cells and increasing CD + 8T cells.The expression of the costimulatory molecule CD 28 on T cells was significantly lower compared with normal controls (P
