THE ANTIATHEROSCLEROTIC EFFECT OF THE EXTRACT FROM GRAPE SEED IN C57BL/6J MICE
- VernacularTitle:葡萄籽提取物对小鼠动脉粥样硬化的作用
- Author:
Guifa XU
;
Hongxia YU
;
Shue WANG
;
Fengrong HAO
;
Qingjun LIU
- Publication Type:Journal Article
- Keywords:
grape seed extract;
athersclerosis;
score of aortic lesion;
blood lipid
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the antiatherosclerotic effect of the extract from grape seed in C57BL/6J mice. Method: The mice were fed with atherosclerotic diet for 20 w and then with basic diet or different dosage of grape seed extract for 4 w. The blood samples were examined for blood lipid. The sections of aorta were examined and scored microscopically. Results: After fed with atherogenic diet for 20 w, the aortic score was 7.2?1.3 and TG, Chol and MDA in serum were significantly increased. After fed with the extract of grape seed for 4 w, the aortic score was reduced to 6.0?1.2, and TG, TC, and MDA levels also decreased. Conclusion: The extract of grape seed has antiatherosclerotic effect.
