Expression of cell cycle regulatory proteins in renal tubulointerstitial cells of human glomerulo- ncphritis
- VernacularTitle:细胞周期调控蛋白在人类肾小球肾炎中肾小管及间质细胞的表达及其意义
- Author:
Yu ZENG
;
Rengui WEI
;
Yijuan LI
- Publication Type:Journal Article
- Keywords:
Kidney tubuls;
Renal interstitium;
Cell cycle regulatory protein;
Immunohistochemistry
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of cell cycle regulatory protiens in renal tubulointerstitial cells of human glomerulonephritis. Methods Immunohisochemieal studies were performed on 19 specimen from renal biopsy to detect cyclin Dl, cyclin A, p21 and proliferating nuclear antigen (PCNA) . Results Cyclin Dl, cyclin A and p21 were positive in some of tubulointerstitial cells, and showed significant correlations with positive PCNA cells. The numbers of tubular positive cells in both groupsofⅠand Ⅱ degree of histopathological change were more than those of other groups. The numbers of interstitialpositive cells showed significant correlations with the degree of tubulointerstitial histopathological change and the value of urine NAG. Conclusion Cell cycle regulatory proteins regulate the proliferation of tubular and interstitial cells, and correlate with the interstitial fibrosis.
