Relationship between paraoxonase 2 A148G polymorphism and diabetic nephropathy
- VernacularTitle:对氧磷酯酶基因多态性与糖尿病肾病的关系
- Author:
Yunling HAO
;
Lixiang UN
;
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Nephropathy;
Paraoxonase 2;
Gene;
Polymorphism
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether the paraoxonase2 (PON2) gene A148G polymorphism is associated with the pathogenesis of nephropathy in type 2 diabetes mellitus patients (DN) . Methods PON2 genotype distribution and allele frequency were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) . Serum immune reactive insulin (IRI) and C-peptide (C-P) concentrations were measured by radioimmunity. Results GG genotype and G allele frequency were higher in DN group than that in simple type 2 diabetes mellitus group (x2 =4. 26 P
