Astragalus and Angelica mixture antagonizes the growth inhibition effect induced by dexamethasone in rats with nephrotic syndrome
- VernacularTitle:芪归合剂拮抗地塞米松对肾病综合征大鼠生长的抑制作用
- Author:
Xiaoyun JIANG
;
Shumei CHEN
;
Ying MO
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome;
Insulin-like growth factor;
Astragalus;
Angelica;
Dexamethasone
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Astragalus and Angelica mixture on growth failure induced by dexaraethasone in rats with nephrotic syndrome (NS) . Methods Forty six-week old male Sprague-Dawley rats with a starting weight of 160 ~ 180 g were randomly divided into five groups: control group, NS model group, NS group treated with Astragalus and Angelica mixture, NS group treated with dexamethasone, and NS group treated with Astragalus and Angelica mixture and dexamethasone. Weight, length, urine protein, and serum albuine were measured. Serum and urine concentrations of IGF-1 and IGFBP-3 were assayed by RIA and IRMA respectively; and IGF-1 mRNA and IGFBP-3 mRNA levels in liver were assayed by RT-PCR. Results Weight gain and length gain, serum IGF-1 and IGFBP-3 levels in NS model group were significantly lower than that of the control group and urine IGF-1 levels were higher than that of the control group (P
