Analysis of the expression of bcl-2 in osteogenic tumor and tumor-diseases
- VernacularTitle:对成骨性肿瘤及瘤样病变bcl-2表达的分析
- Author:
Yong WANG
;
Xingyan LIU
;
Baofeng GE
- Publication Type:Journal Article
- Keywords:
Bone tumor;
Osteoblast;
Immunohistology
- From:
Journal of Clinical Surgery
2002;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investingate the expression method of bcl-2 and it's significance in osteogenic tumor and tumor-like diseases.Method The protein of PCNA, p53, Fas and bcl-2 were examined immunohistologically in osteosarcoma, ossifying fibroma, fibeous dysplasia of bone and normal bone callus. The results were analysed combing with the information of metastasis and hisomorphology.Results PCNA and p53 were highly expressed in low-differentiated osteosarcoma, bcl-2 were highly expressed at high-differentiated osteocoma and ossifying fibroma. When PCNA, p53 and bcl-2 were all expressed at high level, the metastasis rate was high, when only bcl-2 was expressed at high level, the progmosis was better. Conclusion The mechanism for benign and malignant tumor are different, the benign and low-degree malignant tumor may be caused by over accumulated mutation cells sipported by high level of bcl-2, while malignant tumor may be the result of multi-gene cooperation abnormally.
