Study of follicular helper T lymphocytes related cytokines and receptors in children with systemic lupus erythematosus
10.3969/j.issn.1671-8348.2014.21.001
- VernacularTitle:系统性红斑狼疮患儿外周血滤泡辅助性T细胞相关细胞因子及受体表达水平研究
- Author:
Jie ZHAO
;
Li ZENG
;
Yuan CHEN
;
Laicheng LIU
;
Dapeng CHEN
- Publication Type:Journal Article
- Keywords:
lupus erythematosus,systemic;
child;
interleukin-21;
chemohine CCL13;
follicular helper T lymphocytes
- From:
Chongqing Medicine
2014;(21):2689-2690,2694
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of the plasma concentrations of follicular helper T lymphocytes (TFH cells) related cytokines and receptors in children with systemic lupus erythematosus (SLE) .Methods The plasma concentrations of TFH-cells-related cytokine IL-21 and CXCL13 ,and cell surface expression of TFH-related receptor CXCR5 and IL-21R on CD19+B cells in 22 SLE children and 20 sex-and age matched control subjects were measured by enzyme-linked immunosorbent assay and flow cytome-try ,respectively .Results Plasma CXCL13 and IL-21 concentrations were significantly higher in SLE children than controls (all P<0 .01) .Cell surface expression of CXCR5 on B cells was significantly lower in SLE children than controls (P<0 .05) .However ,the cell surface expression of IL-21R had no significant changes between SLE children and controls(P>0 .05) .Conclusion The elevat-ed production of CXCL13 and IL-21 may be associated with the function of TFH for the immunopathogenesis in SLE children .
