The Meta analysis of the different treatments of peri-and postmenopausal women with depressive disorder
10.3969/j.issn.1671-8348.2014.21.009
- VernacularTitle:围绝经和绝经后期抑郁不同治疗方案的M eta分析
- Author:
Wenqian ZHANG
;
Zhengai XIONG
;
Jia JIA
;
Zhiliang WANG
- Publication Type:Journal Article
- Keywords:
perimenopause;
postmenopause;
depression;
mood disorder;
antidepressant;
hormone replacement therapy
- From:
Chongqing Medicine
2014;(21):2712-2715,2719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the curative effect of different therapeutic regimen in perimenopausal and postmenopausal pa-tients with depressive disorder ,in order to guide clinical work .Methods Relevant literatures were collect by retrieving a number of online database ,,screen documents independent ,the randomized controlled trial(RCT) and cohort study were included ,and carried on the quality evaluation and data extractione ,then completed the Meta analysis .Results 19 papers were inclouded (2 312 cases) , including 10 RCT papers and 9 cohort papers .There was no statistically significant difference for cure rate (RR=1 .15 ,P=0 .07) , the difference of effective rate had statistically significant (RR=1 .17 ,P=0 .005) .Hormone in combination with antidepressants compared with hormone replacement therapy :the difference of cure ratio (RR=1 .73 ,P=0 .003) and effective rate (RR=1 .52 , P<0 .01) all had statistically significant .The difference of effective rate between antidepressants and hormone replacement therapy had statistically significant (RR=1 .37 ,P=0 .003) .Hormone replacement therapy compared with placebo :the difference of cure rate had statistically significant(RR=2 .17 ,P=0 .03) ,the difference of effective rate had no statistically significant (RR= 0 .78 ,P=0 .15) .Conclusion Although the hormone replacement therapy has a positive effect on the mood ,it′s promoting effect on the anti-depressant of perimenopausal and postmenopausal women is uncertain .
