Influence of fluoxertin on level of IL-2,IL-6 and TNF-αin brain tissue and serum of rats with post-stroke depression
10.3969/j.issn.1671-8348.2014.21.020
- VernacularTitle:氟西汀对卒中后抑郁大鼠脑组织及血清中IL-2、IL-6及TNF-α表达的影响
- Author:
Libo ZHAO
;
Lu XU
;
Keke CHE
;
Bin QIN
- Publication Type:Journal Article
- Keywords:
interleukin-2;
interleukin-6;
tumor necrosis factor-alpha;
fluoxetine;
post-stroke depression
- From:
Chongqing Medicine
2014;(21):2747-2748,2752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of fluoxertin on level of IL-2 ,IL-6 and TNF-α in brain tissue and serum of rats with post-stroke depression(PSD) .Methods 60 rats were divided into sham operation group ,depression group ,stroke group ,PSD group and fluoxertin group ,12 cases in each group .ELISA was used to detect the level of IL-2 ,IL-6 and TNF-αin brain tissue and serum .Results The level of IL-2 ,IL-6 and TNF-αin depression group ,stroke group and PSD group were significantly increased and higher than that in sham operation group and fluoxertin group(P<0 .05) .There was no significant difference between sham op-eration group and fluoxertin group(P>0 .05) .Conclusion Fluoxertin could significantly decrease the level of IL-2 ,IL-6 and TNF-αand play an important role in therapy of PSD .