Effects of glucomanan on nitric oxide, endothelin and lipid peroxidation in atheroscierotic rabbits
- VernacularTitle:魔芋葡甘聚糖对动脉粥样硬化家兔血清一氧化氮、血浆内皮素和脂质过氧化物的影响
- Author:
Hong LIU
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
nitric oxide;
endothelin;
lipid peroxide;
glucomanan
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of glucomanan on nitric oxide (NO), endothelin (ET), lipid peroxide and superoxide dismutase (SOD) in experimental atherosclerotic rabbits. METHODS: An atherosclerotic rabbit model was established by feeding high cholesterol diet supplemented by bovine serum albumin injection bolus. The rabbits were randomly divided into the control, model, and glucomanan treatment group. Blood samples were collected 8 weeks after the treatment. RESULTS: After glucomanan administration for 8 wk, the NO and activity of SOD increased in comparison with model group (P
